Article
Effects of endocrine disruptors on imprinted gene expression in the mouse embryo.
Epigenetics - 1 Jul 2011
Kang Eun-Rim, Iqbal Khursheed, Tran Diana A, Rivas Guillermo E, Singh Purnima, Pfeifer Gerd P, Szabó Piroska E
Abstract excerpt
Environmental endocrine disruptors (EDs) are synthetic chemicals that resemble natural hormones and are known to cause epigenetic perturbations. EDs have profound effects on development and fertility. Imprinted genes had been identified as susceptible loci to environmental insults by EDs because they are functionally haploid, and because the imprints undergo epigenetic resetting between generations. To screen for...
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