Article
BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children.
European journal of pediatrics - 1 Jun 2010
Hsueh Kai-Chung, Lin Ying-Ju, Chang Jeng-Sheng, Wan Lei, Tsai Fuu-Jen
Abstract excerpt
The butyrophilin-like 2 (BTNL2) gene is a member of the B7 receptor family that probably functions as a T cell costimulatory molecule. Because altered T cell functions are implicated in dysregulation of the immune response seen in Kawasaki disease (KD), it is reasonable to speculate that BTNL2 gene is involved in the pathophysiology of KD. The purpose of this study was to investigate whether polymorphisms of the...
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