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Article

Karyotyping, FISH, and PCR in Acute Lymphoblastic Leukemia

28 Nov 2009

Abstract excerpt

BACKGROUND: Chromosomal abnormalities, such as t(9;22)(q34;q11) (ABL/BCR), t(12;21)(p13;q22) (TEL/AML1), and t(11q23) (MLL) are independent prognostic indicators in childhood acute lymphoblastic leukemia resulting in risk adapted therapy. Accurate and rapid detection of these abnormalities is mandatory, which is achieved by karyotyping, fluorescence in situ hybridization, and real time quantitative reverse...

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PMID: 19875970
DOI: 10.1097/mph.0b013e3181bc9c85

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