Article
Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis.
Journal of the neurological sciences - 15 Apr 2008
Galimberti Daniela, Scalabrini Diego, Fenoglio Chiara, De Riz Milena, Comi Cristoforo, Venturelli Eliana, Cortini Francesca, Piola Mirko, Leone Maurizio, Dianzani Umberto, D'Alfonso Sandra, Monaco Francesco, Bresolin Nereo, Scarpini Elio
Abstract excerpt
Macrophage-derived chemokine (MDC/CCL22) plays a role in Experimental Autoimmune Encephalomyelitis (EAE), the animal model of Multiple Sclerosis (MS). MDC/CCL22 gene is part of a chemokine cluster, which includes also thymus and Activation-Regulated Chemokine (TARC/CCL17). The frequency of the C/T and C/A Single Nucleotide Polymorphisms (SNPs) in the promoter and coding sequence of CCL22 as well as the C/T SNP in...
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