Article
Suppression of Langerhans cell activation is conserved amongst human papillomavirus α and β genotypes, but not a µ genotype.
Virology - 1 Mar 2014
Da Silva Diane M, Movius Carly A, Raff Adam B, Brand Heike E, Skeate Joseph G, Wong Michael K, Kast W Martin
Abstract excerpt
Human papillomavirus (HPV) has evolved mechanisms that allow it to evade the human immune system. Studies have shown HPV-mediated suppression of activation of Langerhans cells (LC) is a key mechanism through which HPV16 evades initial immune surveillance. However, it has not been established whether high- and low-risk mucosal and cutaneous HPV genotypes share a common mechanism of immune suppression. Here, we...
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