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Article

Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX.

Nucleic acids research - 1 Jan 2010

Brotherton Paul, Sanchez Juan J, Cooper Alan, Endicott Phillip

Abstract excerpt

The analysis of targeted genetic loci from ancient, forensic and clinical samples is usually built upon polymerase chain reaction (PCR)-generated sequence data. However, many studies have shown that PCR amplification from poor-quality DNA templates can create sequence artefacts at significant levels. With hominin (human and other hominid) samples, the pervasive presence of highly PCR-amplifiable human DNA...

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Identifiers

PMID: 19864251
DOI: 10.1093/nar/gkp897
PMCID: PMC2811011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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