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Article

Effect of vitamins C and E on toxicity and mutagenicity of hexavalent chromium in rat and guinea pig.

Mutation research - 1 Jan 1991

Chorvatovicová D, Ginter E, Kosinová A, Zloch Z

Abstract excerpt

The effect of simultaneous pretreatment with vitamins C and E on the toxicity and mutagenicity of K2Cr2O7 in rats and guinea pigs was evaluated. Dietary pretreatment of Cr(VI)-intoxicated rats with ascorbic acid or alpha-tocopherol normalized vitamin C levels in lungs but not in kidneys. The synergistic preventive effect of both vitamins was confirmed in the production of lipoperoxides in Cr(VI)-intoxicated rats....

Topics

Adrenal Glands
Animals
Ascorbic Acid
Drug Synergism
Guinea Pigs
Kidney
Liver
Lung
Male
Mutation
Potassium Dichromate
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Inbred Strains

Testis

Vitamin E

Source

Identifiers

PMID: 1986283
DOI: 10.1016/0165-7992(91)90104-c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1986283-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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