Article
Comparative study of the antimutagenic properties of vitamins C and E against mutation induced by norfloxacin.
BMC pharmacology - 11 Feb 2008
Alba Myriam Arriaga, Sánchez Roberto Rivera, Pérez Nancy Jannet Ruíz, Navarrete Jaime Sánchez, Paz Rocío Flores, Montoya-Estrada Araceli, Gómez Juan José Hicks
Abstract excerpt
BACKGROUND: Norfloxacin like other fluoroquinolones, is known to mbe mutagenic for Salmonella typhimurium TA102 strain. This mutagenic effect is due to free oxygen radicals (ROS), because it is inhibited by antioxidants such as beta-carotene and naturally occurring antioxidants of Roheo discolor and other plants. The aim of this work was to evaluate combination therapy with norfloxacin and vitamins C and E, to...
Topics
- Animals
- Anti-Bacterial Agents
- Antimutagenic Agents
- Ascorbic Acid
- Biotransformation
- Mutagenicity Tests
- Mutagens
- Mutation
- Norfloxacin
- Rats
- Salmonella typhimurium
- Vitamin E