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Latent membrane protein 1 encoded by Epstein–Barr virus induces telomerase activity via p16<sup>INK4A</sup>/Rb/E2F1 and JNK signaling pathways

27 Jun 2007

Abstract excerpt

Elevated telomerase activity is observed in about 90% of human cancers. This activity correlates strictly with human telomerase reverse transcriptase (hTERT). Previously, it was shown that the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induced telomerase activity in nasopharyngeal carcinoma cells. In this study, it was indicated that LMP1 inhibited p16(INK4A) expression, promoted phosphorylation...

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Share to Cell death mechanisms and regulation
Share to Cytomegalovirus and herpesvirus research
Share to Telomeres, Telomerase, and Senescence

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PMID: 17597480
DOI: 10.1002/jmv.20896

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