Article
Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner.
Molecular and cellular biology - 1 Jan 2010
Eliyahu Erez, Pnueli Lilach, Melamed Daniel, Scherrer Tanja, Gerber André P, Pines Ophry, Rapaport Doron, Arava Yoav
Abstract excerpt
mRNAs encoding mitochondrial proteins are enriched in the vicinity of mitochondria, presumably to facilitate protein transport. A possible mechanism for enrichment may involve interaction of the translocase of the mitochondrial outer membrane (TOM) complex with the precursor protein while it is translated, thereby leading to association of polysomal mRNAs with mitochondria. To test this hypothesis, we isolated...
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