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Article

Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.

Neurobiology of aging - 1 Aug 2008

Xiao Shangxi, Sato Christine, Kawarai Toshitaka, Goodall Emily F, Pall Hardev S, Zinman Lorne H, Robertson Janice, Morrison Karen, Rogaeva Ekaterina

Abstract excerpt

There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17383054
DOI: 10.1016/j.neurobiolaging.2007.02.022

Genes

GRN
IFT74

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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