The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.

doi:10.1182/blood-2009-05-219808

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The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.

Blood - 11 Feb 2010

Chase Thomas H, Lyons Bonnie L, Bronson Roderick T, Foreman Oded, Donahue Leah Rae, Burzenski Lisa M, Gott Bruce, Lane Priscilla, Harris Belinda, Ceglarek Uta, Thiery Joachim, Wittenburg Henning, Thon Jonathan N, Italiano Joseph E, Johnson Kenneth R, Shultz Leonard D

Abstract excerpt

The spontaneous mouse mutation "thrombocytopenia and cardiomyopathy" (trac) causes macrothrombocytopenia, prolonged bleeding times, anemia, leukopenia, infertility, cardiomyopathy, and shortened life span. Homozygotes show a 20-fold decrease in platelet numbers and a 3-fold increase in platelet size with structural alterations and functional impairments in activation and aggregation. Megakaryocytes in trac/trac...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19846887
DOI: 10.1182/blood-2009-05-219808
PMCID: PMC2826237

Genes

ABCG5
ABCG8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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