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Article

ProPhylER: a curated online resource for protein function and structure based on evolutionary constraint analyses.

Genome research - 1 Jan 2010

Binkley Jonathan, Karra Kalpana, Kirby Andrew, Hosobuchi Midori, Stone Eric A, Sidow Arend

Abstract excerpt

ProPhylER (Protein Phylogeny and Evolutionary Rates) is a next-generation curated proteome resource that uses comparative sequence analysis to predict constraint and mutation impact for eukaryotic proteins. Its purpose is to inform any research program for which protein function and structure are relevant, by the predictive power of evolutionary constraint analyses. ProPhylER currently has nearly 9000 clusters of...

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Identifiers

PMID: 19846609
DOI: 10.1101/gr.097121.109
PMCID: PMC2798826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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