Article
Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach.
European journal of human genetics : EJHG - 1 Apr 2010
Sobrin Lucia, Maller Julian B, Neale Benjamin M, Reynolds Robyn C, Fagerness Jesen A, Daly Mark J, Seddon Johanna M
Abstract excerpt
About 40% of the genetic variance of age-related macular degeneration (AMD) can be explained by a common variation at five common single-nucleotide polymorphisms (SNPs). We evaluated the degree to which these known variants explain the clustering of AMD in a group of densely affected families. We...
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