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Article

Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complex.

Genes & development - 15 Sept 2004

Gewin Lindy, Myers Hadley, Kiyono Tohru, Galloway Denise A

Abstract excerpt

The critical immortalizing activity of the human papillomavirus (HPV) type-16 E6 oncoprotein is to induce expression of hTERT, the catalytic and rate-limiting subunit of telomerase. Additionally, E6 binds to a cellular protein called E6-associated protein (E6-AP) to form an E3 ubiquitin ligase that targets p53 for proteasome-dependent degradation. Although telomerase induction and p53 degradation are separable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15371341
DOI: 10.1101/gad.1214704
PMCID: PMC517520

Genes

NFX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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