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Priming integrin α5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis

20 Oct 2009

Abstract excerpt

Adult human mesenchymal stromal cells (hMSCs) have the potential to differentiate into chondrogenic, adipogenic, or osteogenic lineages, providing a potential source for tissue regeneration. An important issue for efficient bone regeneration is to identify factors that can be targeted to promote the osteogenic potential of hMSCs. Using transcriptome analysis, we found that integrin alpha5 (ITGA5) expression is...

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PMID: 19843692
DOI: 10.1073/pnas.0812334106

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