Article
Relationship between expression of mutant type glutathione S-transferase theta-1 gene and reactivity of rapamycin in myelodysplastic syndrome.
Hematology (Amsterdam, Netherlands) - 1 Oct 2009
Maeda Yasuhiro, Yamaguchi Terufumi, Sasakawa Atsushi, Tanaka Miyako, Morita Yasuyoshi, Kawata Shuhei, Watanabe Katsuya, Hirase Chikara, Takai Shunsuke, Miyatake Junichi, Tatsumi Yoichi, Kanamaru Akihisa
Abstract excerpt
We previously reported mRNA expression of glutathione S-transferases theta (GSTT)-1, wild type (623 bp) and mutant (500 bp), in patients with myelodysplastic syndrome (MDS). The deletion of 123 bp creates a sequence that is homologous to the mammalian target of rapamycin (mTOR). To analyze the function of mutant GSTT-1 gene, stable transformants for the mutant and wild-type GSTT-1 gene, respectively, were...
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