Article
Possible molecular target therapy with rapamycin in MDS.
Leukemia & lymphoma - 1 May 2006
Maeda Yasuhiro, Yamaguchi Terufumi, Hijikata Yasuki, Matsuoka Toshiaki, Tanaka Miyako, Morita Yasuyoshi, Hirase Chikara, Takai Shunsuke, Tatsumi Yoichi, Matsuda Mitsuhiro, Kanamaru Akihisa
Abstract excerpt
The authors previously reported the mRNA expression of Glutathione S-transferases theta (GSTT)-1, wild type (623 bp) and mutant (500 bp) in MDS patients. The deletion of 123 bp creates a sequence that is homologues to mammalian target of rapamycin (mTOR). To analyse the function of mutant GSTT-1 gene, stable transformants for the mutant and wild-type GSTT-1 gene, respectively, were established. In this study, the...
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