Article
F1-dependent translation of mitochondrially encoded Atp6p and Atp8p subunits of yeast ATP synthase.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
Rak Malgorzata, Tzagoloff Alexander
Abstract excerpt
The ATP synthase of yeast mitochondria is composed of 17 different subunit polypeptides. We have screened a panel of ATP synthase mutants for impaired expression of Atp6p, Atp8p, and Atp9p, the only mitochondrially encoded subunits of ATP synthase. Our results show that translation of Atp6p and Atp8p is activated by F(1) ATPase (or assembly intermediates thereof). Mutants lacking the alpha or beta subunits of...
Topics
- Biocatalysis
- DNA, Mitochondrial
- Enzyme Activation
- Gene Dosage
- Gene Expression Regulation, Fungal
- Genes, Suppressor
- Mitochondria
- Mitochondrial Proton-Translocating ATPases
- Mutation
- Protein Biosynthesis
- Protein Subunits
- Proton-Translocating ATPases
- RNA, Messenger