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Article

MdmX is a substrate for the deubiquitinating enzyme USP2a.

Oncogene - 21 Jan 2010

Allende-Vega N, Sparks A, Lane D P, Saville M K

Abstract excerpt

It has previously been shown that ubiquitin-specific protease 2a (USP2a) is a regulator of the Mdm2/p53 pathway. USP2a binds to Mdm2 and can deubiquitinate Mdm2 without reversing Mdm2-mediated p53 ubiquitination. Overexpression of USP2a causes accumulation of Mdm2 and promotes p53 degradation. We now show that MdmX is also a substrate for USP2a. MdmX associates with USP2a independently of Mdm2. Ectopic expression...

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Identifiers

PMID: 19838211
DOI: 10.1038/onc.2009.330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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