Article
Differential role for synaptojanin 1 in rod and cone photoreceptors.
The Journal of comparative neurology - 10 Dec 2009
Holzhausen Lars C, Lewis Alaron A, Cheong Kimberly K, Brockerhoff Susan E
Abstract excerpt
Synaptojanin 1 (SynJ1) is a polyphosphoinositide phosphatase involved in clathrin-mediated endocytosis in conventional synapses. Studies with the zebrafish mutant nrc have revealed that loss of SynJ1 also affects cone photoreceptor ribbon synapses, causing pronounced morphological and functional abnormalities. In this study we continue to examine the role of SynJ1 in photoreceptors. Using a newly generated...
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