Article
Considerations About the Use of Biomarkers in Cancer Clinical Trials.
Clinical pharmacology and therapeutics - 1 Jan 2018
Chabner Bruce A
Abstract excerpt
The rapid evolution of our understanding of cancer biology has affected every phase of patient management, from early detection to drug development and clinical management. Central to this issue is the challenge of using biomarkers to identify the driving mutations present and identifiable by current assays in many tumors. These biomarkers are integral to the process of selecting patients for the testing of new...
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