Article
Angiotensin-converting enzyme and angiotensin II receptor subtype 2 genotypes in type 1 diabetes and severe hypoglycaemia requiring emergency treatment: a case cohort study.
Pharmacogenetics and genomics - 1 Nov 2009
Pedersen-Bjergaard Ulrik, Nielsen Søren L, Akram Kamran, Perrild Hans, Nordestgaard Børge G, Montgomery Hugh E, Pramming Stig, Thorsteinsson Birger
Abstract excerpt
AIMS: In type 1 diabetes, individual susceptibility to severe hypoglycaemia is likely to be influenced by genetic factors. We have previously reported an association of the deletion (D-) allele of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and the A-allele of the angiotensin II receptor subtype 2 (AT2R) 1675 G>A polymorphism with risk of severe hypoglycaemia in such patients....
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