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Article

Phosphodiesterase 8B gene polymorphism in women with recurrent miscarriage: a retrospective case control study.

BMC medical genetics - 13 Dec 2012

Granfors Michaela, Karypidis Helena, Hosseini Frida, Skjöldebrand-Sparre Lottie, Stavreus-Evers Anneli, Bremme Katarina, Landgren Britth-Marie, Sundström-Poromaa Inger, Wikström Anna-Karin, Åkerud Helena

Abstract excerpt

BACKGROUND: Recurrent miscarriage affects approximately 1% of all couples. There is a known relation between hypothyroidism and recurrent miscarriage. Phosphodiesterase 8B (PDE8B) is a regulator of cyclic adenosine monophosphate (cAMP) with important influence on human thyroid metabolism. Single nucleotide polymorphism (SNP) rs 4704397 in the PDE8B gene has been shown to be associated with variations in serum...

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Identifiers

PMID: 23237535
DOI: 10.1186/1471-2350-13-121
PMCID: PMC3556309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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