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Article

Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression.

Gastroenterology - 1 Mar 2010

Kim Seok-Jun, Choi Il-Ju, Cheong Teak-Chin, Lee Sang-Jin, Lotan Reuben, Park Seok Hee, Chun Kyung-Hee

Abstract excerpt

BACKGROUND & AIMS: Galectin-3 is a beta-galactoside-binding protein that increases gastric cancer cell motility in response to integrin signaling and is highly expressed in gastric tumor cells. Galectin-3 induces cytoskeletal remodeling to increase cell motility, but the mechanisms of this process are not understood. We investigated the effects of galectin-3 on fascin-1, an actin-bundling protein. METHODS: We...

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Identifiers

PMID: 19818782
DOI: 10.1053/j.gastro.2009.09.061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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