Article
The ITGAV rs3738919 variant and susceptibility to rheumatoid arthritis in four Caucasian sample sets.
Arthritis research & therapy - 1 Jan 2009
Hollis-Moffatt Jade E, Rowley Kerry A, Phipps-Green Amanda J, Merriman Marilyn E, Dalbeth Nicola, Gow Peter, Harrison Andrew A, Highton John, Jones Peter B B, Stamp Lisa K, Harrison Pille, Wordsworth B Paul, Merriman Tony R
Abstract excerpt
INTRODUCTION: Angiogenesis is an important process in the development of destructive synovial pannus in rheumatoid arthritis (RA). The ITGAV +gene encodes a cell cycle-associated antigen, integrin alphanubeta 3, which plays a role in RA angiogenesis. Previously, two independent studies identified an association between the major allele of the ITGAV single-nucleotide polymorphism (SNP) rs3738919 and RA. We...
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