Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyrosequencing assay to rapidly detect clarithromycin resistance mutations in Canadian Helicobacter pylori isolates.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie - 1 Sept 2009

Slinger R, Yan L, Chan F, Forward K, Cooper-Lesins G, Best L, Haldane D, Veldhuyzen van Zanten S

Abstract excerpt

BACKGROUND: Mutations at positions 2142 or 2143 in the twocopy 23S ribosomal RNA gene of Helicobacter pylori are highly predictive of in vitro clarithromycin resistance and failure of clarithromycin-containing treatment regimens. OBJECTIVE: To design an assay to rapidly detect these mutations using rapid polymerase chain reaction and pyrosequencing, a novel method of 'sequencing by synthesis', and to test this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Canada
Share to Clarithromycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Genes, rRNA

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to RNA, Bacterial

Share to RNA, Ribosomal, 23S

Source

Open in PubMed Open full text

Identifiers

PMID: 19816623
DOI: 10.1155/2009/695349
PMCID: PMC2776549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyrosequencing assay to rapidly detect clarithromycin resistance mutations in Canadian Helicobacter pylori isolates.PMID 19816623Read ↗

Pyrosequencing analysis for rapid and accurate detection of clarithromycin resistance-associated mutations in Iranian Helicobacter pylori isolates.Semantic proximity Read ↗

Gastric wash-based molecular testing for antibiotic resistance in Helicobacter pylori.Semantic proximity Read ↗

Genotypic and Phenotypic Resistance to Clarithromycin in Helicobacter pylori StrainsSemantic proximity Read ↗

Modified allele-specific primer-polymerase chain reaction method for analysis of susceptibility of Helicobacter pylori strains to clarithromycin.Semantic proximity Read ↗

Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing.Semantic proximity Read ↗

Whole-genome sequencing of clarithromycin resistant Helicobacter pylori characterizes unidentified variants of multidrug resistant efflux pump genesSemantic proximity Read ↗

Identification of a 23S rRNA Gene Mutation in Clarithromycin‐Resistant Helicobacter pyloriSemantic proximity Read ↗

Detection of A2143G, A2142C, and A2142G Point Mutations with Real-Time PCR in Stool Specimens from Children Infected with Helicobacter pyloriSemantic proximity Read ↗

Analysis of Helicobacter pylori genotypes in clinical gastric wash samples.Semantic proximity Read ↗

Phenotypic and Molecular Antimicrobial Susceptibility of Helicobacter pylori.Semantic proximity Read ↗

Accurate prediction of macrolide resistance in Helicobacter pylori by a PCR line probe assay for detection of mutations in the 23S rRNA gene: multicenter validation study.Semantic proximity Read ↗

Clinical relevance of point mutations in the 23S rRNA gene in Helicobacter pylori eradicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.