Article
Pyrosequencing analysis for rapid and accurate detection of clarithromycin resistance-associated mutations in Iranian Helicobacter pylori isolates.
BMC research notes - 6 Jul 2023
Alavifard Helia, Nabavi-Rad Ali, Baghaei Kaveh, Sadeghi Amir, Yadegar Abbas, Zali Mohammad Reza
Abstract excerpt
BACKGROUND: Treatment of Helicobacter pylori (H. pylori) infection has become challenging following the development of primary antibiotic resistance. A primary therapeutic regimen for H. pylori eradication includes clarithromycin; however, the presence of point mutations within the 23S rRNA sequence of H. pylori contributes to clarithromycin resistance and eradication failure. Thus, we aimed to develop a rapid...
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