Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The proinflammatory cytokine TNF-alpha -308 AA genotype is associated with polyglandular autoimmunity.

Immunological investigations - 1 Jan 2009

Dittmar Manuela, Kaczmarczyk Adam, Bischofs Christian, Kahaly George J

Abstract excerpt

Data regarding polymorphisms of immunoregulatory genes in polyglandular autoimmunity (PGA) are lacking. We have analyzed whether the polymorphism of the proinflammatory cytokine gene TNF-alpha; -308 and mutations of the autoimmune regulator (AIRE) gene were associated with PGA in adults. Sixty-seven patients with PGA and 209 healthy controls were genotyped by multiplex minisequencing with capillary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIRE Protein
Share to Electrophoresis, Capillary
Share to HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DRB1 Chains

Share to Polyendocrinopathies, Autoimmune

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Transcription Factors

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 19811436
DOI: 10.1080/08820130902766092

Genes

TNF
AIRE
TPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The proinflammatory cytokine TNF-alpha -308 AA genotype is associated with polyglandular autoimmunity.PMID 19811436Read ↗

Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease.Semantic proximity Read ↗

Cytokine polymorphisms in patients with autoimmune hemolytic anemia.Semantic proximity Read ↗

TNF-α -308G/A gene polymorphism in bullous pemphigoid and alopecia areata.Semantic proximity Read ↗

The synergistic role of TNFA - 308G/A and IL10 - 1082A/G polymorphisms in ankylosing spondylitis.Semantic proximity Read ↗

Correlation of tumor necrosis factor-α -308G>A polymorphism with susceptibility, clinical manifestations and severity in Behçet syndrome: evidences from an Italian genetic case-control studySemantic proximity Read ↗

Association Of Tumour Necrosis Factor-Alpha -308 G/A Promoter Polymorphism With Susceptibility And Disease Profile Of Rheumatoid Arthritis.Semantic proximity Read ↗

Tumor necrosis factor (TNF)-308, -1031, and angiotensin-converting enzyme (ACE) DD/II polymorphisms' role in Behcet's disease with and without uveitis: a meta-analysis.Semantic proximity Read ↗

CTLA-4 CT60 polymorphism in thyroid and polyglandular autoimmunity.Semantic proximity Read ↗

TNF-α -308 G > A (rs1800629) Polymorphism is Associated with Celiac Disease: A Meta-analysis of 11 Case-Control Studies.Semantic proximity Read ↗

Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility.Semantic proximity Read ↗

Correlation of Tumor Necrosis Factor-α -308G>A Polymorphism with Susceptibility, Clinical Manifestations, and Severity in Behçet Syndrome: Evidences from an Italian Genetic Case-Control Study.Semantic proximity Read ↗

Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.