Article
Genetic changes in somatostatin receptor positive breast tumors.
The Journal of steroid biochemistry and molecular biology - 20 Dec 1990
Bootsma A H, de Klein A, Reubi J C, Zwarthoff E C, Lamberts S W
Abstract excerpt
Forty-nine primary breast tumors were analyzed for the expression of the somatostatin receptor (SSR) and genetic changes in the RB tumor suppressor gene. Twenty-four tumor samples were shown to contain receptors for somatostatin and in eight of these SSR-positive tumors we observed a mutation in the RB gene. However, since also in the group of SSR-negative tumors in eight of the 25 cases an alteration of the RB...
Topics
- Breast Neoplasms
- Female
- Gene Amplification
- Humans
- Mutation
- Oncogenes
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Receptors, Neurotransmitter
- Receptors, Somatostatin
- Retinoblastoma