Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

doi:10.1172/JCI39703

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Article

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.

The Journal of clinical investigation - 1 Nov 2009

Taylor James G, Cheuk Adam T, Tsang Patricia S, Chung Joon-Yong, Song Young K, Desai Krupa, Yu Yanlin, Chen Qing-Rong, Shah Kushal, Youngblood Victoria, Fang Jun, Kim Su Young, Yeung Choh, Helman Lee J, Mendoza Arnulfo, Ngo Vu, Staudt Louis M, Wei Jun S, Khanna Chand, Catchpoole Daniel, Qualman Stephen J, Hewitt Stephen M, Merlino Glenn, Chanock Stephen J, Khan Javed

Abstract excerpt

Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identified. The receptor tyrosine kinase FGFR4 is highly expressed in RMS tissue, suggesting a role in tumorigenesis, although its functional importance has not been defined. Here, we report the...

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PMID: 19809159
DOI: 10.1172/JCI39703
PMCID: PMC2769177

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FGFR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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