Article
Expression patterns of cardiac myofilament proteins: genomic and protein analysis of surgical myectomy tissue from patients with obstructive hypertrophic cardiomyopathy.
Circulation. Heart failure - 1 Jul 2009
Theis Jeanne L, Bos J Martijn, Theis Jason D, Miller Dylan V, Dearani Joseph A, Schaff Hartzell V, Gersh Bernard J, Ommen Steve R, Moss Richard L, Ackerman Michael J
Abstract excerpt
BACKGROUND: Mutations in myofilament proteins, most commonly MYBPC3-encoded myosin-binding protein C and MYH7-encoded beta-myosin heavy chain, can cause hypertrophic cardiomyopathy (HCM). Despite significant advances in structure-function relationships pertaining to the cardiac sarcomere, there is limited knowledge of how a mutation leads to clinical HCM. We, therefore, set out to study expression and...
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