Article
No evidence for loss of alleles at 11p in HBV negative hepatocellular carcinomas.
Genes, chromosomes & cancer - 1 Mar 1990
Kiechle-Schwarz M, Scherer G, Kovacs G
Abstract excerpt
The aim of the present study was to determine whether loss of DNA sequences at the chromosome arm 11p, where presumed tumor suppressor genes are located, might occur in hepatocellular carcinomas (HCCs) of hepatitis B virus (HBV) negative patients. Normal liver and HCC genotypes were compared at 6 loci on 11p with 7 polymorphic probes detecting 10 restriction length polymorphisms (RFLPs). Each of the 8 paired...
Topics
- Alleles
- Carcinoma, Hepatocellular
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- DNA, Neoplasm
- Genotype
- Hepatitis B virus
- Humans
- Liver Neoplasms
- Polymorphism, Restriction Fragment Length