Article
Bioinformatics construction of the human cell surfaceome.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2009
da Cunha J P C, Galante P A F, de Souza J E, de Souza R F, Carvalho P M, Ohara D T, Moura R P, Oba-Shinja S M, Marie S K N, Silva W A, Perez R O, Stransky B, Pieprzyk M, Moore J, Caballero O, Gama-Rodrigues J, Habr-Gama A, Kuo W P, Simpson A J, Camargo A A, Old Lloyd J, de Souza S J
Abstract excerpt
Cell surface proteins are excellent targets for diagnostic and therapeutic interventions. By using bioinformatics tools, we generated a catalog of 3,702 transmembrane proteins located at the surface of human cells (human cell surfaceome). We explored the genetic diversity of the human cell surfaceome at different levels, including the distribution of polymorphisms, conservation among eukaryotic species, and...
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