Article
Surfaceome of classical Hodgkin and non-Hodgkin lymphoma.
Proteomics. Clinical applications - 1 Aug 2015
Hofmann Andreas, Thiesler Thore, Gerrits Bertran, Behnke Silvia, Sobotzki Nadine, Omasits Ulrich, Bausch-Fluck Damaris, Bock Thomas, Aebersold Ruedi, Moch Holger, Tinguely Marianne, Wollscheid Bernd
Abstract excerpt
PURPOSE: Classical Hodgkin lymphoma (cHL) is characterized by a low percentage of tumor cells in a background of diverse, reactive immune cells. cHL cells commonly derive from preapoptotic germinal-center B cells and are characterized by the loss of B-cell markers and the varying expression of other hematopoietic lineage markers. This phenotypic variability and the scarcity of currently available cHL-specific...
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