Article
Evidence for a homodimeric structure of human monocarboxylate transporter 8.
Endocrinology - 1 Nov 2009
Visser W Edward, Philp Nancy J, van Dijk Thamar B, Klootwijk Wim, Friesema Edith C H, Jansen Jurgen, Beesley Philip W, Ianculescu Alexandra G, Visser Theo J
Abstract excerpt
The human monocarboxylate transporter 8 (hMCT8) protein mediates transport of thyroid hormone across the plasma membrane. Association of hMCT8 mutations with severe psychomotor retardation and disturbed thyroid hormone levels has established its physiological relevance, but little is still known about the basic properties of hMCT8. In this study we present evidence that hMCT8 does not form heterodimers with the...
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