Dysregulation of myeloid-specific transcription factors in congenital neutropenia.

Abstract excerpt

Severe congenital neutropenia (CN) is a heterogeneous hematopoietic syndrome with a typical "maturation arrest" of granulocytic precursors at the promyelocytic stage, inherited in an autosomal dominant or recessive manner. Intriguingly, CN patients have the same bone marrow and blood phenotypes irrespective of inheritance. This suggests that mutations in various genes may lead to the dysregulation of the common...

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