Genetic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.

doi:10.1111/gbb.70018

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Genetic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.

Genes, brain, and behavior - 1 Apr 2025

King Christopher P, Chitre Apurva S, Leal-Gutiérrez Joel D, Tripi Jordan A, Netzley Alesa H, Horvath Aidan P, Lamparelli Alexander C, George Anthony, Martin Connor, St Pierre Celine L, Missfeldt Sanches Thiago, Bimschleger Hannah V, Gao Jianjun, Cheng Riyan, Nguyen Khai-Minh, Holl Katie L, Polesskaya Oksana, Ishiwari Keita, Chen Hao, Robinson Terry E, Flagel Shelly B, Solberg Woods Leah C, Palmer Abraham A, Meyer Paul J

Abstract excerpt

Addiction vulnerability is associated with the tendency to attribute incentive salience to reward predictive cues. Both addiction and the attribution of incentive salience are influenced by environmental and genetic factors. To characterize the genetic contributions to incentive salience attribution, we performed a genome-wide association study (GWAS) in a cohort of 1596 heterogeneous stock (HS) rats. Rats...

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PMID: 40049657
DOI: 10.1111/gbb.70018
PMCID: PMC11884905

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