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Infection and Killing of Multiple Myeloma by Adenoviruses

29 Sept 2009

Abstract excerpt

Oncolytic virotherapy makes use of the natural ability of viruses to infect and kill cancer cells. Adenovirus serotype 5 (Ad5) has been approved for use in humans as a therapy for solid cancers. In this study, we have tested whether Ad5 and low-seroprevalence adenoviruses can be used as oncolytics for multiple myeloma (MM). We show that Ad5 productively infects most myeloma cell lines, replicates to various...

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PMID: 19788385
DOI: 10.1089/hum.2009.082

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