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Article

Methylenetetrahydrofolate reductase C677T genotype and PD.

Annals of neurology - 1 Jun 2005

de Lau Lonneke M L, Koudstaal Peter J, van Meurs Joyce B J, Uitterlinden André G, Hofman Albert, Breteler Monique M B

Abstract excerpt

In a prospective, population-based cohort study among 5,920 participants aged 55 years or older, we observed that the TT variant of the methylenetetrahydrofolate reductase C677T polymorphism is associated with an increased risk for Parkinson's disease in smokers. Both smoking and the TT genotype are known to induce hyperhomocystinemia, and synergistic effects on homocysteine levels have been reported. Increased...

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Source

Identifiers

PMID: 15929053
DOI: 10.1002/ana.20509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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