Article
Prevalence of hepatitis B virus DNA polymerase mutations in treatment-naïve patients with chronic hepatitis B.
Alimentary pharmacology & therapeutics - 1 Dec 2009
Nguyen M H, Garcia R T, Trinh H N, Nguyen H A, Nguyen K K, Nguyen L H, Levitt B
Abstract excerpt
BACKGROUND: One of the most important factors in treatment failure using nucleos(t)ide analogues in chronic hepatitis B is anti-viral resistance. Primary drug resistance refers to amino acid changes in the hepatitis B virus polymerase/reverse transcriptase (rt) that result in reduced susceptibili...
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