Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.

doi:10.1371/journal.pone.0007154

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Article

Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.

PloS one - 28 Sept 2009

Villani Alexandra-Chloé, Lemire Mathieu, Louis Edouard, Silverberg Mark S, Collette Catherine, Fortin Geneviève, Nimmo Elaine R, Renaud Yannick, Brunet Sébastien, Libioulle Cécile, Belaiche Jacques, Bitton Alain, Gaudet Daniel, Cohen Albert, Langelier Diane, Rioux John D, Arnott Ian D R, Wild Gary E, Rutgeerts Paul, Satsangi Jack, Vermeire Séverine, Hudson Thomas J, Franchimont Denis

Abstract excerpt

BACKGROUND AND AIMS: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD)...

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Identifiers

PMID: 19784369
DOI: 10.1371/journal.pone.0007154
PMCID: PMC2745755

Genes

MEFV
NLRP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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