Article
Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect?
Digestive diseases and sciences - 1 Apr 2006
Giaglis Stavros, Mimidis Konstantinos, Papadopoulos Vassilios, Thomopoulos Konstantinos, Sidiropoulos Prodromos, Rafail Stavros, Nikolopoulou Vassiliki, Fragouli Eleni, Kartalis Georgios, Tzioufas Athanasios, Boumpas Dimitrios, Ritis Konstantinos
Abstract excerpt
The MEFV gene, responsible for familial Mediterranean fever (FMF), is involved in inflammatory reactions through altered leukocyte apoptosis, secretion of interleukin (IL)-1beta, and activation of the NF-kappa B pathway. Ulcerative Colitis (UC) and FMF are both characterized by a recurrent pattern of presentation with periods of remission and flares associated with neutrophilic infiltration at the site of injury....
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