Developmental regulation of cardiovascular function is dependent on both genotype and environment.

doi:10.1152/ajpheart.01338.2008

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Article

Developmental regulation of cardiovascular function is dependent on both genotype and environment.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2009

Knight Brian S, Sunn Nana, Pennell Craig E, Adamson S Lee, Lye Stephen J

Abstract excerpt

Adverse developmental environments can increase the risk of adult cardiovascular disease, but not all individuals are affected, suggesting the importance of genotype. Genetically distinct mouse strains allow the genetic dissection of complex traits; however, they have not been used to evaluate the developmental origins of adult cardiovascular disease. Our objective was to determine the effect of prenatal nutrient...

Topics

Age Factors
Aging
Animals
Blood Pressure
Caloric Restriction
Cardiovascular Diseases
Cardiovascular System
Dietary Fats
Environment
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heart Rate

Hypertension

Male

Maternal Nutritional Physiological Phenomena

Mice

Mice, Inbred C57BL

Myocardial Contraction

Source

Open in PubMed

Identifiers

PMID: 19783772
DOI: 10.1152/ajpheart.01338.2008

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