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Article

Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010

Wermter Anne-Kathrin, Kamp-Becker Inge, Hesse Philipp, Schulte-Körne Gerd, Strauch Konstantin, Remschmidt Helmut

Abstract excerpt

An increasing number of animal studies advert to a substantial role of the neuropeptide oxytocin in the regulation of social attachment and affiliation. Furthermore, animal studies showed anxiety and stress-reduced effects of oxytocin. First human studies confirm these findings in animal studies and implicate a crucial role of oxytocin in human social attachment behavior and in social interactions. Thus, the...

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Source

Identifiers

PMID: 19777562
DOI: 10.1002/ajmg.b.31032

Genes

OXTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level.PMID 19777562Read ↗

Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population.Semantic proximity Read ↗

Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition.Semantic proximity Read ↗

The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis.Semantic proximity Read ↗

Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder.Semantic proximity Read ↗

Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD.Semantic proximity Read ↗

Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes.Semantic proximity Read ↗

The oxytocin receptor gene polymorphism -rs237902- is associated with the severity of autism spectrum disorder: A pilot study.Semantic proximity Read ↗

Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder.Semantic proximity Read ↗

Genetic variation in the oxytocin receptor gene is associated with a social phenotype in autism spectrum disorders.Semantic proximity Read ↗

Associations between oxytocin-related genes and autistic-like traits.Semantic proximity Read ↗

Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.Semantic proximity Read ↗

Functional characterization of an oxytocin receptor gene variant (rs2268498) previously associated with social cognition by expression analysis in vitro and in human brain biopsy.Semantic proximity Read ↗

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