Article
Phosphorylation of Williams syndrome transcription factor by MAPK induces a switching between two distinct chromatin remodeling complexes.
The Journal of biological chemistry - 20 Nov 2009
Oya Hiroyuki, Yokoyama Atsushi, Yamaoka Ikuko, Fujiki Ryoji, Yonezawa Masayoshi, Youn Min-Young, Takada Ichiro, Kato Shigeaki, Kitagawa Hirochika
Abstract excerpt
Changes in the environment of a cell precipitate extracellular signals and sequential cascades of protein modification and elicit nuclear transcriptional responses. However, the functional links between intracellular signaling-dependent gene regulation and epigenetic regulation by chromatin-modifying proteins within the nucleus are largely unknown. Here, we describe novel epigenetic regulation by MAPK cascades...
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