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Article

Loss of ATRX in chondrocytes has minimal effects on skeletal development.

PloS one - 23 Sept 2009

Solomon Lauren A, Li Jennifer R, Bérubé Nathalie G, Beier Frank

Abstract excerpt

BACKGROUND: Mutations in the human ATRX gene cause developmental defects, including skeletal deformities and dwarfism. ATRX encodes a chromatin remodeling protein, however the role of ATRX in skeletal development is currently unknown. METHODOLOGY/PRINCIPAL FINDINGS: We induced Atrx deletion in mouse cartilage using the Cre-loxP system, with Cre expression driven by the collagen II (Col2a1) promoter. Growth rate,...

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Source

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Identifiers

PMID: 19774083
DOI: 10.1371/journal.pone.0007106
PMCID: PMC2744333

Genes

ATRX
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of ATRX in chondrocytes has minimal effects on skeletal development.PMID 19774083Read ↗

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