Article
Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.
The Journal of allergy and clinical immunology - 1 Oct 2009
Hitomi Yuki, Ebisawa Motohiro, Tomikawa Morimitsu, Imai Takanori, Komata Takatsugu, Hirota Tomomitsu, Harada Michishige, Sakashita Masafumi, Suzuki Yoichi, Shimojo Naoki, Kohno Yoichi, Fujita Kimie, Miyatake Akihiko, Doi Satoru, Enomoto Tadao, Taniguchi Masami, Higashi Noritaka, Nakamura Yusuke, Tamari Mayumi
Abstract excerpt
BACKGROUND: NLR family, pyrin domain containing 3 (NLRP3), controls the activity of inflammatory caspase-1 by forming inflammasomes, which leads to cleavage of the procytokines IL-1beta and IL-18. Recent studies have shown associations of human NLRP3 polymorphisms with susceptibility to various inflammatory diseases; however, the association with allergic diseases remains unclear. OBJECTIVE: We sought to examine...
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