Hepatocytes explanted in the spleen preferentially express carbamoylphosphate synthetase rather than glutamine synthetase.

doi:10.1002/hep.1840120414

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Article

Hepatocytes explanted in the spleen preferentially express carbamoylphosphate synthetase rather than glutamine synthetase.

Hepatology (Baltimore, Md.) - 1 Oct 1990

Lamers W H, Been W, Charles R, Moorman A F

Abstract excerpt

Urea cycle enzymes and glutamine synthetase are essential for NH3 detoxification and systemic pH homeostasis in mammals. Carbamoylphosphate synthetase, the first and flux-determining enzyme of the cycle, is found only in a large periportal compartment, and glutamine synthetase is found only in a...

Topics

Age Factors
Animals
Carbamoyl-Phosphate Synthase (Ammonia)
Cell Communication
Gene Expression Regulation, Enzymologic
Glutamate-Ammonia Ligase
Liver
Liver Transplantation
Phenotype
Rats
Rats, Inbred Strains
Spleen

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