Article
The establishment of the hepatic architecture is a prerequisite for the development of a lobular pattern of gene expression.
Development (Cambridge, England) - 1 Jan 1996
Notenboom R G, de Boer P A, Moorman A F, Lamers W H
Abstract excerpt
We have studied the expression patterns of ammonia-metabolising enzymes and serum proteins in intrasplenically transplanted embryonic rat hepatocytes by in situ hybridisation and immunohistochemical analysis. The enzymic phenotype of individually settled hepatocytes was compared with that of hepatocytes being organised into a three-dimensional hepatic structure. Our results demonstrate that development towards...
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